Which skin lesion is characterized by its dome shape and is typically benign?

The skin lesion characterized by a dome shape and is typically benign is keratoacanthoma. This type of lesion often presents as a smooth, rounded nodule with a central keratin plug, giving it the dome-like appearance. Although keratoacanthomas can resemble squamous cell carcinoma, they are often considered a variant that usually resolves on its own over time. Their benign nature, alongside the dome shape, helps in distinguishing them from more concerning lesions.

Other lesions listed differ in characteristics and behavior. Acrochorda, or skin tags, are also benign but typically appear as small, fleshy growths rather than dome-shaped nodules. Epidermal cysts are generally well-defined but may not have a dome shape and can be filled with keratin. Basal cell carcinoma, while often presenting as a nodular lesion, is not considered benign and typically requires treatment due to its potential for local invasion.